Axiobio · 100% Chitosan Hemostatics
Axiostat L88 Hemostatic Patch
Pure 100% chitosan hemostatic patch — no gauze substrate, no coatings. The only hemostatic patch on the market where chitosan is the material itself. Designed for surface wounds, facial trauma, difficult-to-pack areas, and surgical hemostasis where fast, bioadhesive clot formation is critical.
Key Specifications
| Active Agent | 100% Chitosan — no gauze substrate, no coating |
| Format | Flat patch (L88 configuration) — for surface and accessible wound application |
| Hemostasis Mechanism | Bioadhesive — pure chitosan forms instant electrostatic bond with blood cells and platelets |
| Claimed Hemostasis Time | Under 30 seconds (per Axiobio clinical data) |
| Primary Applications | Surface lacerations, facial wounds, surgical hemostasis, difficult-to-pack areas |
| Anticoagulant Compatibility | Effective regardless of coagulation status — cascade-independent mechanism |
| Manufacturer | Axiobio Technologies (India) |
| Sterility | Sterile, single-use, sealed packaging |
Why Axiostat L88 Patch
Only 100% Chitosan Patch
Unlike chitosan-coated gauze products where chitosan is a surface treatment on a fabric carrier, Axiostat L88 is made entirely of chitosan. Every fiber in contact with the wound is active hemostatic material — no dilution by an inert substrate.
Patch Format for Hard Areas
The L88 flat patch format is engineered for wounds where gauze packing is impractical — facial lacerations, scalp wounds, broad surface trauma, and surgical field hemostasis. Apply directly, press and hold.
Instant Bioadhesion
Pure chitosan is highly bioadhesive to wet tissue. On contact with blood and wound surfaces, the patch adheres and begins forming a stable clot matrix within seconds — critical in high-movement or difficult-to-hold positions.
Mechanism of Action: Pure Chitosan Bioadhesive Hemostasis
Axiostat uses 100% chitosan — a cationic (positively charged) biopolymer derived from crustacean shells. When the patch contacts blood, the positively charged chitosan surface creates an intense electrostatic attraction to the negatively charged surface of red blood cells and platelets. This drives rapid cellular aggregation and physical clot formation directly at the wound interface.
Because the L88 is 100% chitosan (no inert gauze backing), the entire material surface in contact with the wound is active. This contrasts with chitosan-coated products where only the surface layer of fibers carries the active agent — Axiostat delivers maximum chitosan surface exposure to the wound.
This is cascade-independent hemostasis: it does not require fibrinogen activation, thrombin generation, or a functional clotting cascade. The clot forms via a physical bioadhesive mechanism, making Axiostat effective in hypothermic casualties, patients on anticoagulants, and dilutional coagulopathy scenarios.
Field & Clinical Applications
The patch format conforms to facial contours where gauze packing is not practical. Bioadhesion keeps it in place on wet, curved surfaces.
Used in operative settings to control diffuse surgical bleeding from tissue beds where suture ligation is not practical.
For broad surface wounds from shrapnel, glass, or blunt trauma where immediate hemorrhage control before suturing is needed.
Particularly valuable in civilian emergency medicine where patients on blood thinners or with bleeding disorders present with traumatic hemorrhage.
Who Uses Axiostat L88 Patch
Surgeons & OR Teams
Applied intraoperatively for diffuse hemorrhage control from tissue beds, anastomosis sites, or parenchymal surfaces.
Tactical Medics & EMTs
Field personnel needing a fast, no-pack option for facial trauma and surface wounds under operational conditions.
Civilian Emergency Responders
First responders and civilians encountering traumatic bleeding from road accidents, industrial incidents, and mass casualty events.
More From MED-TAC International
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Compliance Notice: This product is intended for use by trained medical personnel and trained first responders. Application without appropriate training may result in suboptimal outcomes. Always follow your organization's established trauma protocols. Not a substitute for definitive surgical care. Visit tactical-medicine.com for training resources.
When to Choose Axiostat L88 Patch
- Facial & Scalp Hemorrhage — When a wound cannot be packed with traditional rolled gauze — facial lacerations, scalp avulsions, periorbital wounds — the flat patch format allows direct application and maintained contact without packing technique.
- Surgical Bleeding Control — In OR settings where diffuse parenchymal or tissue-bed bleeding requires a bioadhesive hemostatic material applied directly to the surgical field.
- Anticoagulated Casualties — Patients on oral anticoagulants, aspirin, or with underlying coagulopathies benefit from chitosan's cascade-independent mechanism. The L88 patch is especially practical where compression alone is insufficient.
- Maximum Chitosan Density Needed — When you need the highest possible chitosan-to-wound contact, the 100% pure chitosan construction of Axiostat delivers more active agent per surface area than chitosan-coated alternatives.
- Speed-Critical Scenarios — Axiobio's claimed sub-30-second hemostasis time makes the L88 appropriate when time to control is the primary concern and wound geometry allows patch application.
Axiostat L88 vs. Alternatives
- vs. QuikClot Combat Gauze (kaolin) — QuikClot is a CoTCCC-recommended rolled gauze for wound packing and uses kaolin to activate the intrinsic coagulation cascade. Axiostat L88 is a flat patch that works cascade-independently via pure chitosan bioadhesion — suited for non-packable surface wounds. Different tools for different wound geometries.
- vs. ChitoGauze (chitosan-coated gauze) — ChitoGauze is a woven gauze fabric with a chitosan surface coating — CoTCCC-recommended for wound packing. Axiostat L88 is 100% chitosan (no carrier substrate) in a patch format. ChitoGauze wins for deep cavity packing; Axiostat L88 wins for surface wounds and maximum chitosan density.
- vs. HemCon Bandage (chitosan patch) — HemCon is one of the original chitosan-based bandages. Both use chitosan's bioadhesive mechanism. Axiostat L88's 100% pure chitosan construction (vs. chitosan-coated backing on some HemCon variants) may offer higher active agent density. HemCon has extensive historical military use data.
- vs. Axiostat Z-Fold Gauze — Both are Axiobio products using 100% pure chitosan. The Z-Fold is for wound packing (deep cavities, junctional wounds). The L88 patch is for surface application. Choose Z-Fold for packable wounds; choose L88 for wounds requiring patch application.
- vs. Standard Gauze Dressings — Standard gauze provides mechanical compression only. Axiostat L88 adds active hemostatic chemistry — the chitosan drives clot formation rather than simply absorbing blood. Significantly more effective for arterial and high-pressure venous bleeding.
Frequently Asked Questions
Q: What does "100% chitosan" mean — how is Axiostat different from other chitosan products?
A: Most chitosan hemostatics apply chitosan as a coating on top of a woven gauze fabric carrier. The gauze provides structure but the chitosan is only on the surface. Axiostat is made entirely of chitosan — the material itself is the biopolymer, with no inert fabric substrate. This means every surface in contact with the wound is active hemostatic chitosan, not inert backing material.
Q: Is Axiostat L88 CoTCCC-recommended?
A: Axiostat is not currently listed on the TCCC guidelines as a CoTCCC-recommended hemostatic agent. It is a clinically validated chitosan-based hemostatic used in surgical and emergency medicine contexts. CoTCCC recommendation requires specific U.S. military trauma validation processes that Axiostat has not completed as of current guidelines.
Q: How fast does Axiostat L88 achieve hemostasis?
A: Axiobio claims hemostasis in under 30 seconds based on their clinical data. The bioadhesive pure chitosan material begins bonding to red blood cells and platelets on contact, forming a stable clot matrix rapidly. Results vary by wound type, blood pressure, and coagulation status.
Q: Can Axiostat L88 be used for wound packing?
A: The L88 patch format is optimized for surface application — flat wounds, facial trauma, surgical fields, and accessible lacerations. For wound packing of deep cavities, junctional wounds, and gunshot wound channels, the Axiostat Z-Fold Hemostatic Gauze is the appropriate Axiobio format.
Q: Who manufactures Axiostat?
A: Axiostat is manufactured by Axiobio Technologies, an Indian biotech company. Axiobio has developed Axiostat as its core hemostatic platform and distributes it for both surgical and emergency medical applications globally, including through distributors such as MED-TAC International.
Specifications coming soon. Contact us for detailed product information.
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