Axiobio · 100% Chitosan Hemostatics
Axiostat Z-Fold Hemostatic Gauze
100% pure chitosan hemostatic gauze in Z-fold format — engineered for deep wound packing of junctional, cavity, and extremity wounds. No inert gauze substrate. Every layer is active chitosan, delivering maximum hemostatic density for the most demanding trauma scenarios.
Key Specifications
| Active Agent | 100% Chitosan — no gauze substrate, no coating |
| Format | Z-fold configuration — accordion-folded for rapid deployment and wound packing |
| Hemostasis Mechanism | Cascade-independent — pure chitosan electrostatic bioadhesive clot formation |
| Primary Applications | Deep wound packing, junctional hemorrhage, extremity GSW/stab wounds, cavity wounds |
| Anticoagulant Compatibility | Effective regardless of coagulation status — mechanism does not require clotting cascade |
| vs. Chitosan-Coated Gauze | 100% chitosan (no inert substrate) vs. chitosan surface coating on woven fabric |
| Manufacturer | Axiobio Technologies (India) |
| Sterility | Sterile, single-use, sealed packaging |
Why Axiostat Z-Fold Gauze
Full-Depth Chitosan Saturation
Because the gauze is 100% chitosan — not chitosan coated onto an inert fabric — every fiber throughout the entire material cross-section is active. When packed into a deep wound, maximum hemostatic material contacts the bleeding source.
Z-Fold for Rapid Deploy
The accordion-style Z-fold format unravels predictably under pressure, allowing the packer to maintain direct finger pressure while feeding gauze into the wound cavity — reducing the chance of inadvertent air gaps in the packed wound.
Junctional & Cavity Capable
Designed for the wounds that kill fastest: groin, axilla, neck, and thoracic cavity — areas where tourniquet placement is not possible and deep packing is the definitive pre-hospital intervention.
Mechanism of Action: 100% Chitosan Wound Packing
Axiostat Z-Fold uses the same pure chitosan technology as the Axiostat L88 patch — but in a wound-packable format. Chitosan is a cationic biopolymer with a strong positive surface charge. When packed into a hemorrhaging wound cavity, the chitosan fibers encounter the negatively charged surfaces of red blood cells and platelets, driving rapid electrostatic aggregation and forming a dense physical clot.
This is cascade-independent hemostasis: it does not require thrombin, fibrin, or a functional coagulation cascade. This is critical in real trauma scenarios — casualties are frequently hypothermic, in hemorrhagic shock, or on anticoagulants, all of which impair the natural clotting cascade. Chitosan works regardless.
The distinction from chitosan-coated competitors (e.g., ChitoGauze, which applies chitosan as a coating to a woven gauze fabric): in Axiostat, there is no inert substrate diluting the hemostatic material. The chitosan is the gauze. When packed tightly, the entire volume of material in the wound is actively hemostatic — not just the chitosan-coated surface fibers of a fabric carrier.
Field Applications
Groin, axilla, and neck wounds where tourniquet placement is anatomically impossible. Deep packing with chitosan gauze is the primary pre-hospital hemorrhage control option.
Pack wound channels created by ballistic or penetrating trauma to extremities, torso, and limb-root areas. The Z-fold feeds progressively as packing depth increases.
For extremity wounds requiring wound packing as the primary control method, or as adjunct to tourniquet application when wound anatomy makes tourniquet-only control insufficient.
In civilian trauma involving patients on blood thinners or with coagulopathy from hemorrhagic shock, chitosan's cascade-independent mechanism remains effective where traditional hemostatics may underperform.
Who Uses Axiostat Z-Fold Gauze
Tactical Medics & Combat Lifesavers
Operators and medical personnel needing maximum-density chitosan gauze for junctional and cavity wound packing in austere environments.
EMS & Paramedics
Prehospital providers managing high-energy trauma and penetrating wounds before surgical care is available.
Advanced First Responders
Law enforcement, fire rescue, and civilian responders with wound packing training who want pure chitosan hemostatic technology for their trauma kits.
More From MED-TAC International
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Compliance Notice: This product is intended for use by trained personnel. Wound packing is an advanced skill — improper application may result in incomplete hemorrhage control. Always follow your organization's established trauma protocols. Not a substitute for definitive surgical care. Visit tactical-medicine.com for training resources.
When to Choose Axiostat Z-Fold Gauze
- Junctional Hemorrhage — When a tourniquet cannot be placed (groin, axilla, neck), deep wound packing is the primary hemorrhage control technique. Axiostat Z-Fold delivers 100% pure chitosan throughout the packed cavity.
- Maximum Chitosan Density — When you want the highest possible concentration of active hemostatic material in the wound. Unlike chitosan-coated gauze, the entire material volume of Axiostat is chitosan — not just the surface layer.
- Anticoagulated Trauma Patients — Civilian and surgical scenarios where the casualty is on blood thinners (warfarin, DOACs, aspirin) or presents with coagulopathy from hemorrhagic shock. Chitosan works regardless of cascade function.
- Cavity and GSW Wounds — Deep penetrating trauma from gunshots, blades, or shrapnel creating wound cavities that require progressive packing to reach the bleeding source.
- TCCC Complement to CoTCCC Products — When equipping kits beyond primary CoTCCC-recommended inventory and seeking pure-chitosan technology as a secondary or supplemental hemostatic agent.
Axiostat Z-Fold vs. Alternatives
- vs. QuikClot Combat Gauze (kaolin) — QuikClot Combat Gauze is CoTCCC-recommended and uses kaolin to activate the intrinsic coagulation cascade. It is the current military standard. Axiostat Z-Fold uses pure chitosan and works cascade-independently. QuikClot has a deeper formal military validation record. Axiostat Z-Fold offers 100% chitosan density with no inert substrate.
- vs. ChitoGauze (CoTCCC-recommended chitosan gauze) — Both are chitosan-based and use wound packing. ChitoGauze applies chitosan as a coating on a woven fabric carrier and carries CoTCCC recommendation. Axiostat Z-Fold has no inert fabric — the chitosan is the material. Higher active agent density, but without ChitoGauze's formal military validation trail.
- vs. Celox Gauze — Celox uses chitosan in granule or fiber form embedded in a gauze matrix. Both are cascade-independent chitosan hemostatics. Celox has extensive independent published research. Axiostat Z-Fold's 100% chitosan construction distinguishes it as a material rather than a gauze-with-additive.
- vs. Axiostat L88 Patch (same brand) — Both are Axiobio pure chitosan products. The L88 is a flat patch for surface and non-packable wounds. The Z-Fold is for deep wound packing. They are complements, not competitors — select based on wound geometry.
- vs. Rescue Chitosan Gauze (Rhino Rescue) — Rhino Rescue chitosan gauze is a more affordable chitosan-impregnated gauze. Axiostat Z-Fold is 100% pure chitosan with no carrier substrate — potentially higher active agent density. Rhino Rescue is the budget option; Axiostat is the pure-chitosan premium option.
Frequently Asked Questions
Q: What makes Axiostat Z-Fold different from other chitosan hemostatic gauzes?
A: Standard chitosan gauzes apply chitosan as a surface coating on a woven fabric carrier (e.g., ChitoGauze). The woven fabric is the structural material; chitosan is the additive. Axiostat is manufactured from 100% chitosan — there is no inert fabric. The gauze material itself is the hemostatic agent throughout its full thickness, delivering higher active chitosan density per packed volume.
Q: Is Axiostat Z-Fold CoTCCC-recommended?
A: Axiostat is not currently listed as a CoTCCC-recommended hemostatic agent. CoTCCC-recommended products (QuikClot Combat Gauze, ChitoGauze XR Pro, Celox Gauze) have undergone specific U.S. military validation processes. Axiostat is a clinically validated chitosan hemostatic used in surgical and emergency contexts globally, but has not completed that specific CoTCCC pathway.
Q: How do I use the Z-Fold format for wound packing?
A: Open the package and locate the first fold of the Z-fold. Using a gloved index finger, begin pressing the gauze into the deepest point of the wound cavity. Feed the gauze progressively as you pack — the accordion fold allows controlled unraveling while you maintain packing pressure. Pack tightly, filling the entire cavity. Apply firm direct pressure over the wound for 3–5 minutes. Do not remove in the field; leave for surgical personnel.
Q: Can Axiostat Z-Fold be used for junctional wounds?
A: Yes — junctional wounds (groin, axilla, neck) are a primary indication. When a tourniquet cannot be applied due to wound location, deep wound packing with hemostatic gauze is the recommended intervention. The Z-Fold format and pure chitosan construction make Axiostat suitable for this application.
Q: Does the 100% chitosan construction affect removal or wound care after packing?
A: Chitosan is biocompatible and the material will soften when saturated with blood and wound fluid. Removal should be performed by medical personnel in a controlled setting. Do not remove a packed wound in the field once hemostasis has been achieved — disruption of the formed clot risks re-hemorrhage. In surgical settings, irrigation aids in removal.
Specifications coming soon. Contact us for detailed product information.
FREQUENTLY ASKED QUESTIONS
